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There are two types of anabolics:Class-I)These are mostly the oil-based injectibles.They work primarily by binding to and activating the androgen receptor,which then interacts with your DNA,sending out various signals to impact anabolism/anti-catabolism.Class-II)These are primarily 17alpha-alkylated oral compounds.They,unlike their oil-based counterparts,do not bind well to the androgen receptor,and acheivetheir effects on growth/strength independent of this process,by binding to other types of receptors.The above study just offers some actual scientific proof into this,and sheds light on why it is beneficial at times to stack steroids from opposing groups,so as toget the maximum results through multiple pathways,as opposed to one primary mechanism...So basically it means you should stack a Test (whatever ester), a 17aa steroid, and maybe if you want some other type of Class 1 steroid. For optimal results.This is basically common sense, but good that there is scientific results to back it.Nothing puts mass on as efficiently as it,except for maybe tren.But unlike tren,testosterone only has ‘mediocre’ binding capacity to the A/R,being far outshinedby deca and primo in the binding capacity department.Yet it provides much better overall growth.Why?It outshines the above aforementioned anabolics in theClass-II mechanisms,such as influences on GH,IGF-1,activation of satellite cells into full maturation,activation of prostaglandin receptors,etc...I believe that non-A/R mediated activity is UNDERRATED if anything on it’s influences on growth.Man child-That’s exactly right.There are two steroids that possess DUAL activity(both class-I & II),and that is testosterone and tren.For this reason,they shouldform the base of your cycle.Tren has the strongest binding capacity to the androgen receptor of ANY steroid,therefore adding a class-I with it probably isnt necessary,as it’s more than sufficient in that department.It’s class-II activity isn’t as aggressive ,therefore adding in a class-II oral such as winstrol or dianabol wouldwork very well.As for testosterone,,the same applies.Throw in an oral compound and a class-I,such as deca,eq,or primobolan,and you’ve got all the bases foranabolism completely covered.Now all you need is the right training stimulation ,and ample nutrition, and you’re on your way to explosive growth...Your wish is my command, lol...Anabolic Steroids achieve their effects on hypertrophy through different mechanisms,and as such are classified into two different categories,class-I and class-IIcompounds.I will explain which ones work through which pathway,and how to effectively combine opposing groups to maximize potentiation of one anotherfor explosive growth....Class-I-These are steroids who’s primary influence on anabolism is achieved through aggressive binding and activation of the androgen receptor...Examples ofpotent class-I’s are-Deca-durabolin,primobolan,equipoise,oxandrolone...Class-II-These are compounds with potent activity independent of A/R binding/activation,and their activity has been monitored in neuron’s,microsomes,mitochondria,etc...Examples of potent class-II’s are-Anadrol,Dianabol,winstrol,Fluoxymesterone...Then we have steroids that are potent combination steroids all by themselves(meaning they display influences on growth through both class-I and II activity,andthus are very effective as’stand-alone’anabolic agents as well as forming the ‘base’ of most steroid stacks)....Two compounds possess this unique characteristic-Trenbelone and Testosterone.Either of these two steroids should form the base of most users stacks,as the cover both A/R and non-A/R mediatedmechanisms,and adding to them with either a class-I or II will only potentiate that particular mechanism towards muscular hypertrophy...Now that we’re aware of which compounds work through which mechanism, how do we combine them effectively to maximize each one’s potential?Asexplained above,Testosterone and trenbelone should form the base of any serious steroid stack,but great effects can be had by combining single mechanismsteroids from opposing classes....
Examples of this type of synergistic combining could be(but are not limited to)

CUTTING:
Winstrol & Equipoise
Winstrol & Primobolan
Fluoxymesterone(Helotestin) & Equipoise or Primobolan

BULKING:
Deca & Dianabol
Anadrol & Equipoise or Primobolan
Winstrol & deca....

And of course,using test or tren as the base compound for either cutting or bulking will only make results that much more explosive. If using test forcutting, an anti-aromitase should be incorporated.